Endocrine Abstracts

Background: Cardiac fibrosis is a common biological response to cardiovascular injury. Maladaptive cardiac fibrosis as observed in patients with hypertension, obesity or diabetes mellitus contributes to contractile dysfunction and electrophysiological disorders. Currently, there is controversy regarding whetherexposure to a high fat diet (HFD) in isolation induces cardiovascular damage and fibrosis. Here, we set out to explore the contribution of different models of obesity to...